Alkali Therapy in Lactic Acidosis
نویسندگان
چکیده
This report attempts to frame the debate about clinical administration of sodium bicarbonate in the setting of lactic acidosis in terms of simple questions. Specifically, we address why we develop lactic acidosis in some circumstances, how acute lactic acidosis impairs cardiovascular function and why sodium bicarbonate may have deleterious effects which limit its utility. We also attempt to explore treatment alternatives to sodium bicarbonate
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Lactic acidosis is a potentially life-threatening metabolic disorder, initiated by an imbalance between lactic acid production and utilization. The only effective treatment is reversal of the cause of the disordered lactic acid metabolism [1]. Intravenous bicarbonate (HCO3 ) administration is often used as an interim treatment to attempt to ameliorate the effects of the acidosis, particularly v...
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متن کاملThe Authors Reply: Alkali Therapy in Patients with Metabolic Acidosis
The Authors Reply: Severe metabolic acidosis can generate detremental clinical effect such as cardiovascular depression and central nervous system dysfunction. It also disturbe important key enzymes’ activity. The effect of bocarbonate therapy aimed at correcting the pH, however, is controversial. Bicarbonate therapy produced CO2 and paradoxically lower the intracellular pH and cerebrospinal fl...
متن کاملAlkali Therapy in Patients with Metabolic Acidosis
The Authors Reply: Severe metabolic acidosis can generate detremental clinical effect such as cardiovascular depression and central nervous system dysfunction. It also disturbe important key enzymes’ activity. The effect of bocarbonate therapy aimed at correcting the pH, however, is controversial. Bicarbonate therapy produced CO2 and paradoxically lower the intracellular pH and cerebrospinal fl...
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